![]() The thyroid hormones, including free T3 (FT3), free thyroxine (FT4), and TSH were measured using a commercially available electrochemiluminescence (ECLIA) kit (Roche). Dyslipidemia was defined according to the Chinese guidelines for the management of dyslipidemia in adults (i.e., TC ≥ 5.2 mmol/L TG ≥ 2.3 mmol/L HDL < 1.0 mmol/L LDL ≥ 4.1 mmol/L). ![]() The SLE disease activity index (SLEDAI) was assessed by qualified rheumatology specialists (B.H., H.W. Eventually, 223 patients were enrolled in this study. Forty-eight patients who had a history of familial hyperlipidemia and/or thyroid disease, diabetes mellitus, and/or other rheumatic diseases, and those who took lipid-lowering agents or thyroid medications were excluded. The study protocol was approved by the Ethics Review Committee of the Affiliated Drum Tower Hospital.Īll SLE patients fulfilled the American College of Rheumatology (ACR) classification criteria for SLE (2009). All patients included in the analysis were informed and agreed to participate in this research. Clinical and laboratory data were collected retrospectively from medical records. ![]() 2017 were recruited consecutively (if informed consent was obtained). A total of 271 patients hospitalized at the Affiliated Drum Tower Hospital of Nanjing University Medical School (Nanjing, China) from Dec. We hypothesized that as a critical metabolic hormone, low FT3 levels may be associated with disease activity and the lipid profile in patients with SLE.Ī single-center, observational and cross-sectional study was performed. The aim of the present study was to explore the prevalence and clinical significance of NTIS in a Chinese cohort with SLE. Nonthyroidal illness syndrome (NTIS also known as low triiodothyronine syndrome or euthyroid sick syndrome) is also prevalent in SLE and characterized by decreased serum T3, normal to low thyroxine (T4), and thyroid-stimulating hormone (TSH) levels. ![]() Importantly, dyslipidemia is associated with disease activity (e.g., kidney damage and cardiovascular disease), and is closely related to the long-term prognosis of SLE patients. Dyslipidemia, characterized as increased total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and/or decreased high-density lipoprotein (HDL) levels in the serum, is prevalent in SLE patients with an incidence ranging between 18.1% and 75%. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production in women of childbearing age. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper.įunding: This study was supported by Nanjing Medical Science and Technique Development Foundation (Z.C., ZKX16039). Received: DecemAccepted: MaPublished: April 16, 2020Ĭopyright: © 2020 Zhang et al. PLoS ONE 15(4):Įditor: Deyu Fang, Northwestern University Feinberg School of Medicine, UNITED STATES (2020) Clinical significance of non-thyroidal illness syndrome on disease activity and dyslipidemia in patients with SLE. Citation: Zhang X, Liu L, Ma X, Hu W, Xu X, Huang S, et al.
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